Channel - BCCDC 2019 RESEARCH WEEK
1/22/2022 6:48:57 AM
Channel Videos
Source vs."Sink"; Examination of Carbapenin Producing Enterobacterales in Hospital Plumbing
Amy Mathers
Carbapenemase producing Enterobacterales are recognized as one of the most urgent groups of antimicrobial resistant bacteria. Most carbapenemase genes are carried on mobile genetic elements which can be exchanged between bacteria via horizontal gene transfer. Recent
recognition of the wastewater premise plumbing’s involvement in carbapenemase producing organisms has highlighted some of
the challenges posed to infection control management including the refactor nature of several interventions. Using recent clinical experiences coupled
with next generation sequencing, we will examine how plumbing may act as a source of transmission, a reservoir for persistence and a location for gene exchange
for some of the most resistant Gram negative bacteria seen in modern hospitals.
BC CDC Presenters
10/22/2019 5:15:00 PM
A Real World Resistance Profile of Virologic Failures Collected from an International Collaboration (SHARED) 2019 Update
Anita Howe
Hepatitis C patients who failed Direct-Acting Antivirals (DAA) often selected
viruses with drug resistance-associated substitutions that limit treatment options.
SHARED, Surveillance of Hepatitis C Antiviral Resistance, Epidemiology
and Methodology, is an international collaboration to study HCV drug resistance
and transmission through sharing data, methods, software and technologies.
Recent data merger suggested that nearly 90% of the patients who failed
therapy selected resistant viruses, and novel mutations previously not observed
during clinical trials were detected in real-world clinic.
BC CDC Presenters
10/24/2019 6:05:00 PM
Collaborative Data Governance to Support First Nations-led Overdose Surveilance and Data Analysis in BC
Soha Sabeti, Chloé Xavier
First Nations in BC have been disproportionately affected by the overdose
crisis. In response to the Public Health Emergency, surveillance systems were
established to identify trends in overdose. Existing systems contained minimal
information on overdose among First Nations. Data linkage, sharing, and analysis
processes that adhered to the principles of OCAP and TRC’s Calls to Action
required development. In response to this need, the First Nations Health Authority,
BCCDC, Provincial Health Officer, and MoH worked collaboratively to
create new data linkage processes to identify First Nations persons in overdose
data. This presentation will outline the data governance context, principles, and
operational considerations of creating overdose surveillance systems for First
Nations people in BC.
BC CDC Presenters
10/24/2019 6:20:00 PM
Evaluation of the Provincial Infectious Syphilis Partner Notification Program among Men who have Sex with Men in BC, Canada
Venessa Ryan
Infectious syphilis rates have been increasing in British Columbia (BC), primarily
among gay, bisexual, and other men who have sex with men (gbMSM).
Partner notification (PN) is a key strategy to preventing and controlling infectious
syphilis. We evaluated PN outcomes along a cascade-of-care from partner
identification, notification, testing, to subsequent diagnosis of infectious syphilis.
We compared outcomes for partner notified by patients versus providers to
inform areas that may benefit from further investment.
BC CDC Presenters
10/24/2019 5:50:00 PM
Examining the Impacts of Illicit Overdose Death on Solid Organ Transplantation
Caren Rose
Opioid overdoses claimed 4460 lives in Canada in 2018 (1/3 of these in BC). As the
overdose crisis continues, one consequence is its role in changing the landscape
of solid organ transplantation (SOT). In 2018, 25% of deceased organ donors in
BC died as a result of overdose, doubling the rate in previous years. Donation
rates are climbing with increased overdose deaths, yet theoretical concerns about
donors with increased risk of HIV/HepC/HepB remain a barrier to optimizing
use of organs from all potential donors. This retrospective registry study provides
estimates of disease transmission and short-term survival after SOT, in order to
confirm the safe use of SOT from overdose donors.
BC CDC Presenters
10/22/2019 7:35:00 PM
Harnessing Genomics Methods and Partnerships across BC to Tackle the Ongoing Rise of CPO in BC
Linda Hoang
Carbapenemase producing organisms, bacteria that are resistant
to one of the last resort class of antibiotics, continue to be
imported from endemic countries to BC healthcare facilities, and
spread within and across BC healthcare facilities. Through innovative
genomics methods, coupled with provincial surveillance,
and in collaboration with health authority infection prevention
and control programs, we can better map and respond to this antimicrobial
resistant threat to our patients and population.
BC CDC Presenters
10/24/2019 7:05:00 PM
Improving Naloxone Access through Community Pharmacies in BC
Zahara Mamdani
The BC Take Home Naloxone (THN) program, established in 2012, provides
naloxone to individuals at risk, or likely to witness, an opioid overdose, primarily
through community-based organizations and harm reduction sites. In December
2017, the THN program expanded to selected community pharmacies across BC
in order to further increase access of naloxone, specifically to those who may be
reluctant to obtain it from traditional harm reduction sites. The evaluation of the
THN program in community pharmacies was conducted to identify strengths
and barriers to the implementation of the program, and inform its improvement.
BC CDC Presenters
10/22/2019 7:05:00 PM
KALAMITea – Kombucha Alcohol Levels Affecting Mothers, Infants and Toddlers
Sung Sik Jang
Kombucha is a popular fermented beverage made from sweetened black tea
and culture. During fermentation bacteria and yeast will convert sugars into
a vinegar-based carbonated beverage. However, if fermentation is incomplete
or continues after bottling ethanol may form. Non-alcoholic beverages sold in
BC should have alcohol by volume (ABV) levels at or below 1%. We conducted
a survey of kombucha teas in BC this summer to evaluate if ABV, excess acids
(pH below 2.5) or E. coli were issues in these beverages. We partnered with BCIT
researchers who detected ethanol using validated head space GC-MS methods.
Results demonstrated specific brands of kombucha tea had ABV1%; the highest
ethanol level (3.4%) to date was found in a mango flavored bottled kombucha
tea purchased in a retail store in central Vancouver.
BC CDC Presenters
10/24/2019 6:35:00 PM
Long Term Mortality in People Treated for Tuberculosis
Kamila Romanowski
Tuberculosis (TB) is the leading cause of death from a single infectious agent
worldwide. The World Health Organization estimates that, in 2017, 1.6 million
deaths were due to TB. These TB-associated mortality estimates reflect the
number of people with TB who die before starting, or during, TB treatment.
Accumulating research, however, suggests that mortality post-TB treatment
is high, but this data has not been comprehensively assessed. We conducted a
systematic review and meta-analysis to estimate the post-treatment mortality
among TB survivors, and examine differences in mortality risk by demographic
and clinical characteristics.
BC CDC Presenters
10/24/2019 5:20:00 PM
Mortality and Health Care Utilization after a Paramedic Attended Overdose
Amanda Slaunwhite, Jessica Moe
In the last three years there has been a large increase in the proportion of
paramedic-attended overdose events where persons have not been transported
to hospital for reasons including declining transportation. The objective of this
analysis was to measure risk of overdose-related and all-cause mortality in the
year following a paramedic-attended non-fatal overdose event using linked
administrative health data contained in the BC Provincial Overdose Cohort.
BC CDC Presenters
10/24/2019 6:50:00 PM
Near-real-time Syndromic Alerting System for Potential Opioid Overdoses Reported to BC Drug and Poison Information Centre
Sarah B. Henderson
Since declaration of the provincial opioid public health emergency in 2016, British
Columbia continues to see new adulterations to illicit drugs, changes in drug
use habits, and increasing drug potency. Under these conditions the province
is still experiencing an increase in annual deaths from illicit drug overdoses. We
developed a syndromic surveillance system to detect opioid overdoses in data
collected by the Drug and Poison Information Centre (DPIC) in near-real-time,
potentially allowing rapid identification of dangerous changes in the drug supply.
The system incorporates machine learning and free text mining to account for
the evolving nature of public exposure to illicit opioids.
BC CDC Presenters
10/22/2019 5:50:00 PM
Partner Notification Outcomes for Chlamydia and Gonorrhea Case Diagnosed Through Clinics vs GetCheckedOnline in British Columbia
Arina Zamanpour
GetCheckedOnline (GCO) is an internet-based testing service for sexually transmitted
and blood-borne infections in British Columbia that is highly accepted
by clients. Using a matched case-control study, we compared treatment uptake,
engagement in partner notification (PN), and PN outcomes between chlamydia
and/or gonorrhea cases diagnosed through GCO and two provincially-operated
sexually transmitted infection clinics. Using a cascade of care, PN outcomes
were compared between partners of GCO and clinic cases. These findings will
enable us to better understand differences between clients of internet-based
testing services and clinic-based clients, as well as inform our PN strategies.
BC CDC Presenters
10/24/2019 5:35:00 PM
Reconciling Access to Traditional and Other Forms of Healthcare for Indigenous 2S/GBQ People: Results from Sex Now 2018
Harlan Pruden, Ryan Stillwagon
In an era of Truth and Reconciliation, there is a collective responsibility to centre
Indigenous peoples in health research, however there is little research examining
healthcare access for Indigenous Two-Spirit and gay, bisexual, queer (2S/GBQ)
men in Canada. We used a two-eyed seeing approach to descriptively analyze the
2018 Sex Now survey of 2S/GBQ Canadian men, examining access to both traditional
and western forms of healthcare and healing. Led by a Two-Spirit Dry Lab
of Indigenous and non-Indigenous epidemiologists, researchers, and community
activists, these results describe key points of access to healthcare services and
existing gaps for Indigenous 2S/GBQ people in Canada.
BC CDC Presenters
10/22/2019 7:20:00 PM
Recovering influenza virus genomes from wild bird habitats for better avian flu surveillance
Kevin Kuchinski
Avian influenza viruses (AIVs) cause severe disease in poultry and humans, leading
to costly outbreaks in commercial flocks, dangerous zoonotic infections in
farm workers, and the potential for disastrous global pandemics involving novel
flu viruses. Consequently, surveillance of AIVs in wild birds (the source of these
viruses) is a cornerstone of pandemic preparedness and disease prevention in
humans and livestock. We have developed a method for recovering and sequencing
influenza genomes in sediment collected from wetlands habitats. This provides
a novel tool for AIV surveillance in the local wild bird community.
BC CDC Presenters
10/24/2019 5:05:00 PM
THE ASPIRE Mayuge trial: Recruitment Update and Interim Findings - MISSING LAST 2 MINUTES OF AUDIO
Beth Payne
The ASPIRE Mayuge trial is a pragmatic, sequential, cluster randomized trial,
which began recruitment in August 2019 in Mayuge, Uganda. The objective
of the trial is to compare effectiveness of two models of community-based
self-collected HPV testing as a screening tool for cervical cancer in this rural
low-resourced setting. Arm 1 involves door-to-door recruitment of women by
community health workers (CHWs). 64 CHWs were trained and 6 nurses for
facility-based VIA follow-up. Over 600 women of the Arm 1 target of 1066 have
been enrolled to date, with an HPV incidence of 26.7% reflecting tremendous
community support and need for screening.
BC CDC Presenters
10/22/2019 6:05:00 PM
Warm Snowy Days are Associated with Risk of Myocardial Infarction Death
Tom Kosatsky
Evidence suggests an increase in death by myocardial infarction (MI) on days
with snowfall, but this had never been evaluated in the complex climate of British
Columbia. We assessed the relationship between snowfall and MI mortality
across the province from 2009-2017 using a case-crossover design. The odds ratio
[95% confidence interval] on days with heavy snowfall (5 cm) was 1.34 [1.00,
1.80], but the effect was larger on warmer days, possibly due to heavier snow. We
hypothesize that shoveling wet snow and travelling in slushy conditions may be
important mechanisms underlying the link between snowfall and MI mortality.
BC CDC Presenters
10/22/2019 6:50:00 PM
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