Comparison of rates of opioid withdrawal symptoms and reversal of opioid toxicity in patients treated with two naloxone dosing regimens: A retrospective cohort study: Roy Purssell

TEAM: Roy Purssell, Jesse Godwin, Jessica Moe, Jane Buxton, Alexis Crabtree, Andrew Kestler, Chris DeWitt, Frank Scheuermeyer, Shannon Erdelyi, Robert Balshaw, Adrianna Rowe, Christopher K Cochrane, Benjamin Ng, Andy Jiang, Alessia Risi, Vi Ho, Jeffrey R Brubacher When managing opioid overdose (OD) patients, the optimal naloxone regimen should rapidly reverse respiratory depression while avoiding opioid withdrawal. Published administration guidelines have not been validated. Rates of opioid withdrawal symptoms (OW) and reversal of opioid toxicity in patients treated with two naloxone dosing regimens were evaluated. Eighty low dose naloxone (LDN; ≤ 0.15 mg) patients were matched with 299 high dose naloxone (HDN; 0.15 mg) patients. HDN patients were more likely than LDN patients to have OW after initial dose (OR=8.43; 95%CI: 1.96, 36.3; p=0.004) and after any dose (OR=2.56; 95%CI: 1.17, 5.60; p=0.019). HDN patients were more likely to meet reversal criteria after initial dose (OR=2.73; 95%CI:1.19, 6.26; p=0.018) and after any dose (OR=6.07; 95%CI: 1.81,20.3; p=0.003).

BC CDC Presenters

10/14/2020 5:05:00 PM