Darcy Sutherland - Bioinformatic tools for the high-throughput discovery and prioritization of antimicrobial peptides against multi-drug resistant pathogen

The widespread use of conventional antibiotics has accelerated the emergence of multi-drug resistant bacteria, known as “superbugs”. Antimicrobial peptides (AMPs) represent a diverse class of immune molecules produced by all classes of life to fight infection. We present a bioinformatics pipeline to rapidly discover and produce novel AMPs from the expanding collection of genomic resources. Discovered AMPs are validated through antimicrobial susceptibility testing, cytotoxicity testing, and induction of resistance experiments to examine the propensity for bacteria to become resistant to AMPs compared with conventional antibiotics.

Mediasite Presenter

10/27/2022 5:50:00 PM