Suzana Montoya - Antibody response to B/Victoria in pre-teens primed a decade earlier with B/Yamagata vaccine: follow-up investigation of potential childhood imprinting

Immunological imprinting is a phenomenon by which memory responses are preferentially recalled to epitopes shared with ancestral virus to which we were originally primed as children. In this series of investigations, infants and toddlers were primed with trivalent influenza vaccine containing B/Yamagata lineage antigen. Vaccination the next 2 seasons with B/Victoria lineage antigen failed to illicit a strong B/Victoria antibody response, instead back-boosting antibodies to the priming B/Yamagata antigen. In follow-up a decade later, we explore the antibody response in a subset of these children re-vaccinated as pre-teens with quadrivalent vaccine containing changed antigens of both lineages.

Mediasite Presenter

10/25/2022 6:20:00 PM