Dr. Agatha Jassem : Measuring CoV Antigen-Antibody Interactions

TEAM Aaron Liu, Inna Sekirov, Danuta Skowronski, Jun Duan, Muhammad Morshed, Natalie Prystajecky, William Hsiao, Soren Gantt, Agatha Jassem Immunological imprinting by the first coronavirus (CoV) infection in childhood may explain the observed differences in COVID-19 severity. By this “original antigenic sin” hypothesis, infection or vaccination with SARS-CoV-2 may preferentially back-boost antibodies to the original infecting CoV to the detriment of SARS-CoV-2 immune response. We are validating two complementary methods for the comprehensive detection of CoV antibodies: a peptide array called VirScan-CoV and a protein-based immunoassay by Meso Scale Discovery. We will characterize SARS-CoV-2 and other CoV antibody profiles and link to COVID-19 outcomes using established cohorts.

BC CDC Presenters

10/15/2020 6:05:00 PM