Citlali Márquez - Estimating Mpox Prevalence in BC: A Serosurvey Using a Validated Multiplex Assay

Since the global mpox (MPXV) outbreak in 2022, sporadic cases have continued to emerge in BC. However, the true prevalence of mpox in the province has yet to be estimated due to the lack of a specific test capable of detecting past infections. We have now validated a multiplex serological assay that identifies evidence of infection based on specific mpox antigens (E8L, A35R, B6R). Using this assay, we conducted a serosurvey on residual sera samples from males submitted to the BCCDC PHL for routine syphilis testing at two time points: July 2023 and January-March 2024. The samples have been linked to mpox vaccination records to exclude potential cross-reactivity. This study will help estimate the prevalence of infection within a high-risk population in the province.

Mediasite Presenter

10/29/2024 6:20:00 PM