Quantifying the Relationship Between SARS-CoV-2 Vaccine Breakthrough infections and the Production of Infectious Virus

Current vaccines are effective at preventing serious illness due to SARS-CoV-2, but breakthrough infections are expected. Regardless of vaccination status, RT-PCR assays are used to detect and approximate SARS-CoV-2 RNA levels. However, RT-PCR cannot discern between infectious and non-infectious virus and methods are variable. Studies have examined the infectivity of breakthrough SARS-CoV-2 viruses, but do not adjust for important covariates, including age, sex, sampling and testing methods and lineage. Therefore, we summarize known associations to define a set of confounders that will be adjusted for when piloting a study to determine if breakthrough infections produce infectious virus. Chad Fibke, Hind Sbihi, Agatha Jassem, Natalie Prystajecky, John Tyson

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10/18/2021 3:00:00 PM