Fang Fang Li - Detection of enterovirus D antibodies in cerebrospinal fluid of patients with neurological symptoms

Guillain-Barré syndrome (GBS) is an acute inflammatory disorder characterized by immune-mediated damage of the peripheral nerves leading to paralysis. While the exact cause is unknown, cases of GBS can be preceded by acute infection, such as with enterovirus D (EV-D), and diagnosis is thus often supported by molecular testing. However, viral detection by PCR in cerebrospinal fluid (CSF) is often negative, creating a need for antibody testing to support pathogen identification. We demonstrated the usage of a phage-based serological assay to detect antibodies against EV-D peptides in CSF to aid in the etiologic diagnosis of GBS in a pediatric case with evidence of recent EV-D infection.

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10/12/2023 6:20:00 PM