Amee Manges MPH, PhD: Maternal Fecal Microbiome and Early Infant Growth in Rural Zimbabwe

A total of 207 SHINE mothers contributed 354 whole metagenome sequencing datasets (187 during pregnancy). The maternal microbiome did not appear to differ in pregnancy, by HIV-status, or SHINE WASH assignment. Abundance of resistant starch degrading bacteria was important in predicting infant birth weight, and to a lesser extent neonatal growth. Pathogen carriage was low. Capacity for environmental sensing, energy metabolism and vitamin B metabolism were important predictors of increased infant birth weight and neonatal growth; while bacterial functions related to biofilm formation, in response to nutrient restriction, predicted low birth weight. The pregnancy microbiome in rural Zimbabwe is characterized by diet-dependent resistant starch degrading members, which play a role in fetal growth. TEAM: Ethan K. Gough, Thaddeus J. Edens, Hyun Min Geum, Iman Baharmand, Sandeep K. Gill, Ruairi Robertson, Kuda Mutasa, Robert Ntozini, Bernard Chasekwa, Florence D. Majo, Naume V. Tavengwa, Batsirai Mutasa, Freddy Francis, Lynnea Carr, Laura E. Smith, Rebecca Stoltzfus, Lawrence H. Moulton, Andrew J. Prendergast, Jean H. Humphrey,Amee R. Manges and the SHINE Trial Team

BC CDC Presenters

10/13/2020 6:50:00 PM