High resolution characterization of global Salmonella subpopulations using whole genome sequencing data Jimmy Liu

TEAM: Jimmy Liu, William Hsiao Over the course of long evolutionary histories, existing pathogens have adapted to various niches, establishing stable subpopulations that are dessimated globally. The designation of these subpopulations or subtyping is critical for risk assessments and longitudinal surveillance. To date, serotyping remains as the main method for Salmonella subtyping; however, it offers low discriminatory power due to the limited targets of comparison. We compared ~180,000 Salmonella whole genome sequences from 157 countries to differentiate Salmonella subtypes at a higher resolution. We described additional pitfalls of serotyping by revealing the discorrelation between antigenic and core genome variation.

BC CDC Presenters

10/14/2020 10:05:00 PM