Carl Zou - The ecological analysis to explore the association between antibiotic use during infancy and asthma incidence among children 1 to 4 years of age

A growing number of evidence showed an association between antibiotic use and asthma incidence in childhood and breastfeeding found to be protective toward childhood asthma. We conducted an ecological analysis to explore the association between antibiotic use during infancy and asthma incidence among children 1 to 4 years of age. Our Negative Binomial Model showed a significant association between the quintiles of antibiotic prescription and asthma incidence during 2000 to 2014, but the association appeared to weaken during 2015 to 2019. Using the population attributable risk method, we predicted the expected asthma incidence. The predicted incidence closely matched the actual observed incidence, suggesting that changes in factors like breastfeeding rates may play a role in the incidence of asthma.

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10/10/2023 6:50:00 PM