Identification of SARS-CoV-2 Mutational Profiles Associated with Breakthrough Infections

COVID-19 vaccination is a key tool in the pandemic response. However, the emergence of new variants may undermine the efficacy of current vaccines. Mutations in the Spike protein, such as E484K, have been associated with lower vaccine effectiveness. Therefore, we defined a subset of 29,080 samples with 639 breakthrough infection and 2079 distinct spike mutation profiles, which would challenge traditional statistical analysis. We investigate penalized logistic regression’s ability to select mutation profiles associated with breakthrough infections. Identification of breakthrough mutation profiles will help aid future vaccine development and vaccination campaigns. TEAM Yayuk Joffres, Chad Fibke, Natalie Prystajecky John Tyson, Linda Hoang, Naveed Janjua, Mel Krajden, Hind Sbihi

BCCDC POSTER PRESENTER

10/18/2021 3:20:00 PM